Diagnostic tools for monitoring kidney transplant recipients.

Published

Journal Article (Review)

Recent advancements in immunobiology have introduced several new diagnostic tools for monitoring kidney transplant recipients. These have been added to more established tests that, although imperfect, remain important benchmarks of diagnostic utility. Both new and old tests can be characterized with regard to their practicality, and as to whether they detect aberrant function or define the cause of dysfunction. Unfortunately, no current test is both practical and specific to a particular disease entity. Accordingly, the diagnosis of graft dysfunction remains dependent on the proper use and interpretation of many studies. This article reviews the current assays that have been evaluated in the clinic for the diagnosis of renal allograft-related diseases. These are limited to assays based on routinely obtainable samples such as blood, biopsy tissue, and urine. Newer studies are presented, along with more mundane assays, to highlight the practical use of studies regardless of their degree of mechanistic sophistication.

Full Text

Duke Authors

Cited Authors

  • Girlanda, R; Mannon, RB; Kirk, AD

Published Date

  • July 2007

Published In

Volume / Issue

  • 27 / 4

Start / End Page

  • 462 - 478

PubMed ID

  • 17616277

Pubmed Central ID

  • 17616277

Electronic International Standard Serial Number (EISSN)

  • 1558-4488

International Standard Serial Number (ISSN)

  • 0270-9295

Digital Object Identifier (DOI)

  • 10.1016/j.semnephrol.2007.03.007

Language

  • eng