Induction immunosuppression.
Journal Article (Review)
Induction immunosuppression is intense, prophylactic therapy used at the time of transplantation based on the empiric observation that more powerful immunosuppression is required to prevent acute rejection early. In the past decade, there has been a growing trend towards the use of specialized agents such as antibody therapies for induction. In general, these agents have been shown to reduce the rate of acute rejection. However, their use has not been clearly shown to improve long-term transplant outcomes. This overview will review the biological basis for induction immunosuppression and the mechanisms of action of those specialized induction agents currently in clinical use. Clinical trials investigating induction regimens will be evaluated, and an individualized approach to the use of induction immunosuppressants will be presented.
Full Text
Duke Authors
Cited Authors
- Kirk, AD
Published Date
- September 15, 2006
Published In
Volume / Issue
- 82 / 5
Start / End Page
- 593 - 602
PubMed ID
- 16969280
Pubmed Central ID
- 16969280
International Standard Serial Number (ISSN)
- 0041-1337
Digital Object Identifier (DOI)
- 10.1097/01.tp.0000234905.56926.7f
Language
- eng
Conference Location
- United States