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Workshop on late renal allograft dysfunction.

Publication ,  Journal Article
Meyers, CM; Kirk, AD
Published in: Am J Transplant
July 2005

Despite continued improvement in incidence of acute immune injury and short-term graft survival, late allograft dysfunction remains a significant problem in the renal transplant population. Recent reports suggest that rates of renal function decline are quite varied in the overall recipient population, and that individual rates for many recipients may not change substantially over time. Moreover, analyses also reveal distinct predictive factors for both early and late functional decline. Long-term outcome studies for renal transplantation, however, might be significantly limited by incomplete data sets for assessing clinical endpoints. In view of the heterogeneous factors that may cause progressive allograft injury, more routine biopsy sampling would allow a more complete characterization of induced injuries. Elucidating mechanisms of renal fibrosis in response to injury, in experimental systems and humans, is also an important goal in better understanding chronic allograft damage. Regulation of cell senescence genes and epithelial to mesenchymal transition, studied in other models of renal fibrosis, are likely relevant to studies of renal allograft dysfunction. Recent technical advances in analyzing biological samples may play a pivotal role in identifying and validating surrogate markers of allograft function for future interventional trials in transplantation.

Duke Scholars

Published In

Am J Transplant

DOI

ISSN

1600-6135

Publication Date

July 2005

Volume

5

Issue

7

Start / End Page

1600 / 1605

Location

United States

Related Subject Headings

  • Time Factors
  • Surgery
  • Postoperative Period
  • Kidney Transplantation
  • Kidney Diseases
  • Kidney
  • Humans
  • Databases, Factual
  • 3204 Immunology
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Meyers, C. M., & Kirk, A. D. (2005). Workshop on late renal allograft dysfunction. Am J Transplant, 5(7), 1600–1605. https://doi.org/10.1111/j.1600-6143.2005.00926.x
Meyers, Catherine M., and Allan D. Kirk. “Workshop on late renal allograft dysfunction.Am J Transplant 5, no. 7 (July 2005): 1600–1605. https://doi.org/10.1111/j.1600-6143.2005.00926.x.
Meyers CM, Kirk AD. Workshop on late renal allograft dysfunction. Am J Transplant. 2005 Jul;5(7):1600–5.
Meyers, Catherine M., and Allan D. Kirk. “Workshop on late renal allograft dysfunction.Am J Transplant, vol. 5, no. 7, July 2005, pp. 1600–05. Pubmed, doi:10.1111/j.1600-6143.2005.00926.x.
Meyers CM, Kirk AD. Workshop on late renal allograft dysfunction. Am J Transplant. 2005 Jul;5(7):1600–1605.
Journal cover image

Published In

Am J Transplant

DOI

ISSN

1600-6135

Publication Date

July 2005

Volume

5

Issue

7

Start / End Page

1600 / 1605

Location

United States

Related Subject Headings

  • Time Factors
  • Surgery
  • Postoperative Period
  • Kidney Transplantation
  • Kidney Diseases
  • Kidney
  • Humans
  • Databases, Factual
  • 3204 Immunology
  • 3202 Clinical sciences