Strategies for minimizing immunosuppression in kidney transplantation.

Published

Journal Article (Review)

Immunosuppression remains the cause of most morbidity following organ transplantation. However, its use is also responsible for the outstanding graft and patient survival rates commonplace in modern transplantation. Thus, the predominant challenge for transplant clinicians is to provide a level of immunosuppression that prevents graft rejection while preserving immunocompetence against environmental pathogens. This review will outline several strategies for minimizing or tailoring the use of immunosuppressive drugs. The arguments for various strategies will be based on clinical trial data rather than animal studies. A distinction will be made between conventional immunosuppressive drug reduction based on over-immunosuppression, and newer induction methods specifically designed to lessen the need for chronic immunosuppression. Based on the available data we suggest that most patients can be transplanted with less immunosuppression than is currently standard.

Full Text

Duke Authors

Cited Authors

  • Kirk, AD; Mannon, RB; Swanson, SJ; Hale, DA

Published Date

  • January 2005

Published In

Volume / Issue

  • 18 / 1

Start / End Page

  • 2 - 14

PubMed ID

  • 15612977

Pubmed Central ID

  • 15612977

International Standard Serial Number (ISSN)

  • 0934-0874

Digital Object Identifier (DOI)

  • 10.1111/j.1432-2277.2004.00019.x

Language

  • eng

Conference Location

  • England