The clinical application of monoclonal antibody therapies in renal transplantation.

Journal Article (Journal Article;Review)

Monoclonal antibodies have become valuable tools for the precise clinical manipulation of the immune system. These highly specific proteins have proven their usefulness in both the treatment and prevention of organ transplant rejection. Indeed, they are the centrepieces of many evolving regimens designed to reduce or eliminate the need for chronic immunosuppression. This manuscript will review the monoclonal antibodies that have made their way into the clinic either as experimental therapies or approved drugs. It will provide a general overview of this class of agents and their mechanisms of action. Standard therapies and potential new applications will be described.

Full Text

Duke Authors

Cited Authors

  • Dhanireddy, KK; Xu, H; Mannon, RB; Hale, DA; Kirk, AD

Published Date

  • May 2004

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 23 - 37

PubMed ID

  • 15155134

Electronic International Standard Serial Number (EISSN)

  • 1744-7623

Digital Object Identifier (DOI)

  • 10.1517/eoed.


  • eng

Conference Location

  • England