The clinical application of monoclonal antibody therapies in renal transplantation.
Published
Journal Article (Review)
Monoclonal antibodies have become valuable tools for the precise clinical manipulation of the immune system. These highly specific proteins have proven their usefulness in both the treatment and prevention of organ transplant rejection. Indeed, they are the centrepieces of many evolving regimens designed to reduce or eliminate the need for chronic immunosuppression. This manuscript will review the monoclonal antibodies that have made their way into the clinic either as experimental therapies or approved drugs. It will provide a general overview of this class of agents and their mechanisms of action. Standard therapies and potential new applications will be described.
Full Text
Duke Authors
Cited Authors
- Dhanireddy, KK; Xu, H; Mannon, RB; Hale, DA; Kirk, AD
Published Date
- May 2004
Published In
Volume / Issue
- 9 / 1
Start / End Page
- 23 - 37
PubMed ID
- 15155134
Pubmed Central ID
- 15155134
Electronic International Standard Serial Number (EISSN)
- 1744-7623
Digital Object Identifier (DOI)
- 10.1517/eoed.9.1.23.32957
Language
- eng
Conference Location
- England