Tolerance: is it achievable in pediatric solid organ transplantation?

Journal Article (Journal Article;Review)

Significant advances have been made in the understanding of allograft rejection. There is growing awareness that allograft acceptance, or tolerance, is also an active process rather than a passive absence of rejection. Mechanistic awareness of this process has spawned many preclinical strategies for the prevention of allograft rejection without the need for chronic immunosuppression. These therapies are currently entering clinical trials. This article reviews the prevailing therapies that hold promise for future clinical application. In particular, their application in children is discussed, as are biologic aspects of childhood immunity that may play a role in the success or failure of these strategies.

Full Text

Duke Authors

Cited Authors

  • Pearl, JP; Preston, E; Kirk, AD

Published Date

  • December 2003

Published In

Volume / Issue

  • 50 / 6

Start / End Page

  • 1261 - vii

PubMed ID

  • 14710780

International Standard Serial Number (ISSN)

  • 0031-3955

Digital Object Identifier (DOI)

  • 10.1016/s0031-3955(03)00120-2


  • eng

Conference Location

  • United States