Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy.

Journal Article

Renal allograft recipients generally need to take several immunosuppressive agents for life. Calcineurin inhibitors and glucocorticosteroids are the mainstays of most regimens but have undesirable chronic effects. We postulated that aggressive T-cell depletion combined with the newer immunosuppressant sirolimus would permit transplantation without multidrug treatment. We therefore tested T-cell depletion with rabbit antithymocyte globulin followed by sirolimus monotherapy in 12 patients in an open-label study. This approach was tolerated well, and all patients achieved excellent renal function, and most did not need chronic steroid treatment or calcineurin inhibitors. Rejection was typically correlated with low concentrations of sirolimus, indicating continued dependence on maintenance immunosuppression.

Full Text

Duke Authors

Cited Authors

  • Swanson, SJ; Hale, DA; Mannon, RB; Kleiner, DE; Cendales, LC; Chamberlain, CE; Polly, SM; Harlan, DM; Kirk, AD

Published Date

  • November 2002

Published In

Volume / Issue

  • 360 / 9346

Start / End Page

  • 1662 - 1664

PubMed ID

  • 12457792

Electronic International Standard Serial Number (EISSN)

  • 1474-547X

International Standard Serial Number (ISSN)

  • 0140-6736

Digital Object Identifier (DOI)

  • 10.1016/s0140-6736(02)11606-0

Language

  • eng