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Immunosuppression without immunosuppression? How to be a tolerant individual in a dangerous world.

Publication ,  Journal Article
Kirk, AD
Published in: Transpl Infect Dis
March 1999

The field of transplantation has developed based on two principles: allografts are rejected because they express foreign antigens, and the immune system must be suppressed to prevent rejection. Recently, in vitro and in vivo experimental evidence has accumulated that calls both of these beliefs into question. This article reviews an alternative approach to transplantation that focuses on tissue injury as the instigator of graft rejection and employs physiological mechanisms of tolerance to avoid graft loss. Methods that allow for defense against infectious microbes while at the same time allowing for graft survival are proposed. In particular, the rationale behind the use of anti-CD154 antibody treatment is highlighted. A model is introduced that takes into consideration the experimental successes seen with anti-CD154 therapies.

Duke Scholars

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Published In

Transpl Infect Dis

DOI

ISSN

1398-2273

Publication Date

March 1999

Volume

1

Issue

1

Start / End Page

65 / 75

Location

Denmark

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Immunology
  • Surgery
  • Immunosuppressive Agents
  • Immunosuppression Therapy
  • Immune Tolerance
  • Humans
  • Graft Rejection
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Kirk, A. D. (1999). Immunosuppression without immunosuppression? How to be a tolerant individual in a dangerous world. Transpl Infect Dis, 1(1), 65–75. https://doi.org/10.1034/j.1399-3062.1999.10107.x
Kirk, A. D. “Immunosuppression without immunosuppression? How to be a tolerant individual in a dangerous world.Transpl Infect Dis 1, no. 1 (March 1999): 65–75. https://doi.org/10.1034/j.1399-3062.1999.10107.x.
Kirk, A. D. “Immunosuppression without immunosuppression? How to be a tolerant individual in a dangerous world.Transpl Infect Dis, vol. 1, no. 1, Mar. 1999, pp. 65–75. Pubmed, doi:10.1034/j.1399-3062.1999.10107.x.
Journal cover image

Published In

Transpl Infect Dis

DOI

ISSN

1398-2273

Publication Date

March 1999

Volume

1

Issue

1

Start / End Page

65 / 75

Location

Denmark

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Immunology
  • Surgery
  • Immunosuppressive Agents
  • Immunosuppression Therapy
  • Immune Tolerance
  • Humans
  • Graft Rejection
  • 3202 Clinical sciences
  • 1103 Clinical Sciences