Hepatitis C Virus. Strategies to Evade Antiviral Responses.
Publication
, Journal Article
Gokhale, NS; Vazquez, C; Horner, SM
Published in: Future Virol
2014
Hepatitis C virus (HCV) causes chronic liver disease and poses a major clinical and economic burden worldwide. HCV is an RNA virus that is sensed as non-self in the infected liver by host pattern recognition receptors, triggering downstream signaling to interferons (IFNs). The type III IFNs play an important role in immunity to HCV, and human genetic variation in their gene loci is associated with differential HCV infection outcomes. HCV evades host antiviral innate immune responses to mediate a persistent infection in the liver. This review focuses on anti-HCV innate immune sensing, innate signaling and effectors, and the processes and proteins used by HCV to evade and regulate host innate immunity.
Duke Scholars
Published In
Future Virol
DOI
ISSN
1746-0794
Publication Date
2014
Volume
9
Issue
12
Start / End Page
1061 / 1075
Location
England
Related Subject Headings
- Virology
- 3107 Microbiology
- 1108 Medical Microbiology
- 0605 Microbiology
Citation
APA
Chicago
ICMJE
MLA
NLM
Gokhale, N. S., Vazquez, C., & Horner, S. M. (2014). Hepatitis C Virus. Strategies to Evade Antiviral Responses. Future Virol, 9(12), 1061–1075. https://doi.org/10.2217/fvl.14.89
Gokhale, Nandan S., Christine Vazquez, and Stacy M. Horner. “Hepatitis C Virus. Strategies to Evade Antiviral Responses.” Future Virol 9, no. 12 (2014): 1061–75. https://doi.org/10.2217/fvl.14.89.
Gokhale NS, Vazquez C, Horner SM. Hepatitis C Virus. Strategies to Evade Antiviral Responses. Future Virol. 2014;9(12):1061–75.
Gokhale, Nandan S., et al. “Hepatitis C Virus. Strategies to Evade Antiviral Responses.” Future Virol, vol. 9, no. 12, 2014, pp. 1061–75. Pubmed, doi:10.2217/fvl.14.89.
Gokhale NS, Vazquez C, Horner SM. Hepatitis C Virus. Strategies to Evade Antiviral Responses. Future Virol. 2014;9(12):1061–1075.
Published In
Future Virol
DOI
ISSN
1746-0794
Publication Date
2014
Volume
9
Issue
12
Start / End Page
1061 / 1075
Location
England
Related Subject Headings
- Virology
- 3107 Microbiology
- 1108 Medical Microbiology
- 0605 Microbiology