Stimulation strength and focality of electroconvulsive therapy and magnetic seizure therapy in a realistic head model.

Journal Article (Journal Article)

This study examines the characteristics of the electric field (E-field) induced in the brain by electroconvulsive therapy (ECT) and magnetic seizure therapy (MST). The electric field induced by five ECT electrode configurations (bilateral, bifrontal, right unilateral, focal electrically administered seizure therapy, and frontomedial) as well as an MST coil configuration (circular) was computed in an anatomically realistic finite element model of the human head. We computed the maps of the electric field strength relative to an estimated neural activation threshold, and used them to evaluate the stimulation strength and focality of the various ECT and MST paradigms. The results show that the median ECT stimulation strength in the brain is 3-11 times higher than that for MST, and that the stimulated brain volume is substantially higher with ECT (47-100%) than with MST (21%). Our study provides insight into the observed reduction of cognitive side effects in MST compared to ECT, and supports arguments for lowering ECT current amplitude as a means of curbing its side effects.

Full Text

Duke Authors

Cited Authors

  • Lee, WH; Lisanby, SH; Laine, AF; Peterchev, AV

Published Date

  • 2014

Published In

  • Annu Int Conf Ieee Eng Med Biol Soc

Volume / Issue

  • 2014 /

Start / End Page

  • 410 - 413

PubMed ID

  • 25569983

Electronic International Standard Serial Number (EISSN)

  • 2694-0604

Digital Object Identifier (DOI)

  • 10.1109/EMBC.2014.6943615


  • eng

Conference Location

  • United States