Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance.
Publication
, Journal Article
van Duin, D; Cober, ED; Richter, SS; Perez, F; Cline, M; Kaye, KS; Kalayjian, RC; Salata, RA; Evans, SR; Fowler, VG; Bonomo, RA
Published in: Clin Microbiol Infect
December 2014
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing global threat. Here, we describe the prevalence and impact of tigecycline use in a cohort of patients with CRKP bacteriuria nested within a multicentre, prospective study. In the 21-month study period, 260 unique patients were included. Tigecycline was given to 80 (31%) patients. The use of tigecycline during the index hospitalization was significantly associated with the subsequent development of tigecycline resistance in the same patient (OR, 6.13; 95% CI, 1.15-48.65; p 0.03). In conclusion, the use of tigecycline with CRKP bacteriuria is common, and is associated with the subsequent development of tigecycline resistance.
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Published In
Clin Microbiol Infect
DOI
EISSN
1469-0691
Publication Date
December 2014
Volume
20
Issue
12
Start / End Page
O1117 / O1120
Location
England
Related Subject Headings
- Tigecycline
- Sequence Analysis, DNA
- Molecular Sequence Data
- Minocycline
- Middle Aged
- Microbiology
- Male
- Klebsiella pneumoniae
- Klebsiella Infections
- Humans
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van Duin, D., Cober, E. D., Richter, S. S., Perez, F., Cline, M., Kaye, K. S., … Bonomo, R. A. (2014). Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance. Clin Microbiol Infect, 20(12), O1117–O1120. https://doi.org/10.1111/1469-0691.12714
Duin, D. van, E. D. Cober, S. S. Richter, F. Perez, M. Cline, K. S. Kaye, R. C. Kalayjian, et al. “Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance.” Clin Microbiol Infect 20, no. 12 (December 2014): O1117–20. https://doi.org/10.1111/1469-0691.12714.
van Duin D, Cober ED, Richter SS, Perez F, Cline M, Kaye KS, et al. Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance. Clin Microbiol Infect. 2014 Dec;20(12):O1117–20.
van Duin, D., et al. “Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance.” Clin Microbiol Infect, vol. 20, no. 12, Dec. 2014, pp. O1117–20. Pubmed, doi:10.1111/1469-0691.12714.
van Duin D, Cober ED, Richter SS, Perez F, Cline M, Kaye KS, Kalayjian RC, Salata RA, Evans SR, Fowler VG, Bonomo RA. Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance. Clin Microbiol Infect. 2014 Dec;20(12):O1117–O1120.
Published In
Clin Microbiol Infect
DOI
EISSN
1469-0691
Publication Date
December 2014
Volume
20
Issue
12
Start / End Page
O1117 / O1120
Location
England
Related Subject Headings
- Tigecycline
- Sequence Analysis, DNA
- Molecular Sequence Data
- Minocycline
- Middle Aged
- Microbiology
- Male
- Klebsiella pneumoniae
- Klebsiella Infections
- Humans