Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance.

Journal Article (Journal Article)

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing global threat. Here, we describe the prevalence and impact of tigecycline use in a cohort of patients with CRKP bacteriuria nested within a multicentre, prospective study. In the 21-month study period, 260 unique patients were included. Tigecycline was given to 80 (31%) patients. The use of tigecycline during the index hospitalization was significantly associated with the subsequent development of tigecycline resistance in the same patient (OR, 6.13; 95% CI, 1.15-48.65; p 0.03). In conclusion, the use of tigecycline with CRKP bacteriuria is common, and is associated with the subsequent development of tigecycline resistance.

Full Text

Duke Authors

Cited Authors

  • van Duin, D; Cober, ED; Richter, SS; Perez, F; Cline, M; Kaye, KS; Kalayjian, RC; Salata, RA; Evans, SR; Fowler, VG; Bonomo, RA

Published Date

  • December 2014

Published In

Volume / Issue

  • 20 / 12

Start / End Page

  • O1117 - O1120

PubMed ID

  • 24931918

Pubmed Central ID

  • PMC4265572

Electronic International Standard Serial Number (EISSN)

  • 1469-0691

Digital Object Identifier (DOI)

  • 10.1111/1469-0691.12714


  • eng

Conference Location

  • England