The role of B cells in solid organ transplantation.

Published

Journal Article (Review)

The role of antibodies in chronic injury to organ transplants has been suggested for many years, but recently emphasized by new data. We have observed that when immunosuppressive potency decreases either by intentional weaning of maintenance agents or due to homeostatic repopulation after immune cell depletion, the threshold of B cell activation may be lowered. In human transplant recipients the result may be donor-specific antibody, C4d+ injury, and chronic rejection. This scenario has precise parallels in a rhesus monkey renal allograft model in which T cells are depleted with CD3 immunotoxin, or in a CD52-T cell transgenic mouse model using alemtuzumab to deplete T cells. Such animal models may be useful for the testing of therapeutic strategies to prevent DSA. We agree with others who suggest that weaning of immunosuppression may place transplant recipients at risk of chronic antibody-mediated rejection, and that strategies to prevent this scenario are needed if we are to improve long-term graft and patient outcomes in transplantation. We believe that animal models will play a crucial role in defining the pathophysiology of antibody-mediated rejection and in developing effective therapies to prevent graft injury. Two such animal models are described herein.

Full Text

Duke Authors

Cited Authors

  • Kwun, J; Bulut, P; Kim, E; Dar, W; Oh, B; Ruhil, R; Iwakoshi, N; Knechtle, SJ

Published Date

  • April 2012

Published In

Volume / Issue

  • 24 / 2

Start / End Page

  • 96 - 108

PubMed ID

  • 22137187

Pubmed Central ID

  • 22137187

Electronic International Standard Serial Number (EISSN)

  • 1096-3618

Digital Object Identifier (DOI)

  • 10.1016/j.smim.2011.08.022

Language

  • eng

Conference Location

  • England