Simultaneous pancreas-kidney transplantation from donation after cardiac death: successful long-term outcomes.

Published

Journal Article

OBJECTIVE: The outcomes of simultaneous pancreas-kidney (SPK) transplantation with donor organs procured from donation after cardiac death (DCD) are compared with transplants performed with donor organs recovered from donation after brain death (DBD). SUMMARY BACKGROUND DATA: Concerns exist regarding the utilization of pancreata obtained from DCD donors. While it is known that DCD kidneys will have a higher rate of DGF, long-term functional graft survival data for DCD pancreata have not been reported. METHODS: A retrospective review of all DCD SPK transplants performed at a single center was undertaken. RESULTS: Patient, pancreas, and kidney survival at 5 years were similar between DCD and DBD organs. Pancreas function and outcomes were indistinguishable between the 2 modes of procurement. As expected, the DCD kidneys had an elevated rate of DGF, which had no significant long-term clinical impact. CONCLUSION: SPK transplantation using selected DCD donors is a safe and viable method to expand the organ pool for transplantation.

Full Text

Duke Authors

Cited Authors

  • Fernandez, LA; Di Carlo, A; Odorico, JS; Leverson, GE; Shames, BD; Becker, YT; Chin, LT; Pirsch, JD; Knechtle, SJ; Foley, DP; Sollinger, HW; D'Alessandro, AM

Published Date

  • November 2005

Published In

Volume / Issue

  • 242 / 5

Start / End Page

  • 716 - 723

PubMed ID

  • 16244546

Pubmed Central ID

  • 16244546

Electronic International Standard Serial Number (EISSN)

  • 1528-1140

International Standard Serial Number (ISSN)

  • 0003-4932

Digital Object Identifier (DOI)

  • 10.1097/01.sla.0000186175.84788.50

Language

  • eng