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Relationships between sclerosing cholangitis, inflammatory bowel disease, and cancer in patients undergoing liver transplantation.

Publication ,  Journal Article
Knechtle, SJ; D'Alessandro, AM; Harms, BA; Pirsch, JD; Belzer, FO; Kalayoglu, M
Published in: Surgery
October 1995

BACKGROUND: Liver transplantation has emerged as the definitive treatment for primary sclerosing cholangitis (PSC). Its relationships to inflammatory bowel disease and cholangiocarcinoma were evaluated in this series. METHODS: Fifty-three liver transplantations were performed in 41 patients with PSC at the University of Wisconsin from 1986 through 1994. Fourteen of the patients underwent colectomies for inflammatory bowel disease, eight before transplantation and six after transplantation. Five patients had cholangiocarcinoma on the hepatectomy specimen, and another two had been diagnosed before transplantation. RESULTS: Patient survival for PSC without cholangiocarcinoma was 85% and 62% at 2 and 9 years, respectively. No patient with PSC and cholangiocarcinoma has survived 2 years, although two patients were free of disease 11 and 20 months after transplantation. Despite maintenance immunosuppression seven patients with liver transplants had reactivation of inflammatory bowel disease and colon carcinoma developed in three after liver transplantation. CONCLUSIONS: Liver transplantation should be performed early in the course of PSC to avoid the lethal complications of cholangiocarcinoma. Careful colonoscopic follow-up is necessary in patients undergoing transplantation for PSC because immunosuppressive therapy does not necessarily cause inflammatory bowel disease to be quiescent, nor does it reduce the risk of colon carcinoma developing.

Duke Scholars

Published In

Surgery

DOI

ISSN

0039-6060

Publication Date

October 1995

Volume

118

Issue

4

Start / End Page

615 / 619

Location

United States

Related Subject Headings

  • Surgery
  • Retrospective Studies
  • Pancreatic Neoplasms
  • Middle Aged
  • Male
  • Liver Transplantation
  • Inflammatory Bowel Diseases
  • Immunosuppression Therapy
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Knechtle, S. J., D’Alessandro, A. M., Harms, B. A., Pirsch, J. D., Belzer, F. O., & Kalayoglu, M. (1995). Relationships between sclerosing cholangitis, inflammatory bowel disease, and cancer in patients undergoing liver transplantation. Surgery, 118(4), 615–619. https://doi.org/10.1016/s0039-6060(05)80026-1
Knechtle, S. J., A. M. D’Alessandro, B. A. Harms, J. D. Pirsch, F. O. Belzer, and M. Kalayoglu. “Relationships between sclerosing cholangitis, inflammatory bowel disease, and cancer in patients undergoing liver transplantation.Surgery 118, no. 4 (October 1995): 615–19. https://doi.org/10.1016/s0039-6060(05)80026-1.
Knechtle SJ, D’Alessandro AM, Harms BA, Pirsch JD, Belzer FO, Kalayoglu M. Relationships between sclerosing cholangitis, inflammatory bowel disease, and cancer in patients undergoing liver transplantation. Surgery. 1995 Oct;118(4):615–9.
Knechtle, S. J., et al. “Relationships between sclerosing cholangitis, inflammatory bowel disease, and cancer in patients undergoing liver transplantation.Surgery, vol. 118, no. 4, Oct. 1995, pp. 615–19. Pubmed, doi:10.1016/s0039-6060(05)80026-1.
Knechtle SJ, D’Alessandro AM, Harms BA, Pirsch JD, Belzer FO, Kalayoglu M. Relationships between sclerosing cholangitis, inflammatory bowel disease, and cancer in patients undergoing liver transplantation. Surgery. 1995 Oct;118(4):615–619.
Journal cover image

Published In

Surgery

DOI

ISSN

0039-6060

Publication Date

October 1995

Volume

118

Issue

4

Start / End Page

615 / 619

Location

United States

Related Subject Headings

  • Surgery
  • Retrospective Studies
  • Pancreatic Neoplasms
  • Middle Aged
  • Male
  • Liver Transplantation
  • Inflammatory Bowel Diseases
  • Immunosuppression Therapy
  • Humans
  • Female