Skip to main content

Novel immunosuppressive agents in tolerance induction.

Publication ,  Journal Article
Krieger, NR; Knechtle, SJ
Published in: Curr Drug Targets Cardiovasc Haematol Disord
December 2002

Induction of transplantation tolerance remains a much sought-after but elusive goal with a potential promise of rendering patients free of long-term immunosuppressive drugs while maintaining good organ transplant function indefinitely. All currently studied strategies toward transplantation tolerance include using immunosuppressive agents for a limited time period to achieve tolerance. There are a growing number of agents that lend themselves to tolerance induction and these agents are considered herein. Such agents generally fall into the categories of lymphocyte depletion, costimulation blockade, and adjunctive agents such as rapamycin. Preliminary data using donor stem cells suggests that embryonic stem cells may have substantial advantages over conventional donor bone marrow for tolerance induction. These preliminary results are briefly reviewed as well. Tolerance has been achieved in a small number of organ transplant patients and such successes suggest that progress in the clinical arena is happening and is an obtainable result.

Duke Scholars

Published In

Curr Drug Targets Cardiovasc Haematol Disord

DOI

ISSN

1568-0061

Publication Date

December 2002

Volume

2

Issue

2

Start / End Page

97 / 103

Location

Netherlands

Related Subject Headings

  • Immunosuppressive Agents
  • Immune Tolerance
  • Humans
  • Cardiovascular System & Hematology
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Krieger, N. R., & Knechtle, S. J. (2002). Novel immunosuppressive agents in tolerance induction. Curr Drug Targets Cardiovasc Haematol Disord, 2(2), 97–103. https://doi.org/10.2174/1568006023337592
Krieger, N. R., and S. J. Knechtle. “Novel immunosuppressive agents in tolerance induction.Curr Drug Targets Cardiovasc Haematol Disord 2, no. 2 (December 2002): 97–103. https://doi.org/10.2174/1568006023337592.
Krieger NR, Knechtle SJ. Novel immunosuppressive agents in tolerance induction. Curr Drug Targets Cardiovasc Haematol Disord. 2002 Dec;2(2):97–103.
Krieger, N. R., and S. J. Knechtle. “Novel immunosuppressive agents in tolerance induction.Curr Drug Targets Cardiovasc Haematol Disord, vol. 2, no. 2, Dec. 2002, pp. 97–103. Pubmed, doi:10.2174/1568006023337592.
Krieger NR, Knechtle SJ. Novel immunosuppressive agents in tolerance induction. Curr Drug Targets Cardiovasc Haematol Disord. 2002 Dec;2(2):97–103.

Published In

Curr Drug Targets Cardiovasc Haematol Disord

DOI

ISSN

1568-0061

Publication Date

December 2002

Volume

2

Issue

2

Start / End Page

97 / 103

Location

Netherlands

Related Subject Headings

  • Immunosuppressive Agents
  • Immune Tolerance
  • Humans
  • Cardiovascular System & Hematology
  • Animals