Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation.

Journal Article (Journal Article;Review)

Studies in non-human primates to evaluate tolerance strategies in organ transplantation have led to innovation in human transplantation. The two strategies we have studied in detail in non-human primates are T-cell depletion by anti-CD3 immunotoxin and co-stimulation blockade. Each of these strategies has been extended into early human trials in renal transplantation. The results of these human and non-human primate studies are summarized. Continued progress in better and safer immunosuppressive methods remains closely linked to research using non-human primates. However, there has not been a one-to-one correspondence between efficacy in the primate and efficacy in humans. Rather, principles can be derived from non-human primate studies that can be extended into human trials with the knowledge that regimens will likely differ in humans compared to non-human primates.

Full Text

Duke Authors

Cited Authors

  • Knechtle, SJ; Hamawy, MM; Hu, H; Fechner, JH; Cho, CS

Published Date

  • October 1, 2001

Published In

Volume / Issue

  • 183 /

Start / End Page

  • 205 - 213

PubMed ID

  • 11782258

International Standard Serial Number (ISSN)

  • 0105-2896

Digital Object Identifier (DOI)

  • 10.1034/j.1600-065x.2001.1830116.x


  • eng

Conference Location

  • England