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Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation.

Publication ,  Journal Article
Knechtle, SJ; Hamawy, MM; Hu, H; Fechner, JH; Cho, CS
Published in: Immunol Rev
October 2001

Studies in non-human primates to evaluate tolerance strategies in organ transplantation have led to innovation in human transplantation. The two strategies we have studied in detail in non-human primates are T-cell depletion by anti-CD3 immunotoxin and co-stimulation blockade. Each of these strategies has been extended into early human trials in renal transplantation. The results of these human and non-human primate studies are summarized. Continued progress in better and safer immunosuppressive methods remains closely linked to research using non-human primates. However, there has not been a one-to-one correspondence between efficacy in the primate and efficacy in humans. Rather, principles can be derived from non-human primate studies that can be extended into human trials with the knowledge that regimens will likely differ in humans compared to non-human primates.

Duke Scholars

Published In

Immunol Rev

DOI

ISSN

0105-2896

Publication Date

October 2001

Volume

183

Start / End Page

205 / 213

Location

England

Related Subject Headings

  • Transplantation Tolerance
  • Models, Animal
  • Lymphocyte Depletion
  • Kidney Transplantation
  • Immunotoxins
  • Immunology
  • Humans
  • CD40 Ligand
  • CD3 Complex
  • Animals
 

Citation

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Chicago
ICMJE
MLA
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Knechtle, S. J., Hamawy, M. M., Hu, H., Fechner, J. H., & Cho, C. S. (2001). Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation. Immunol Rev, 183, 205–213. https://doi.org/10.1034/j.1600-065x.2001.1830116.x
Knechtle, S. J., M. M. Hamawy, H. Hu, J. H. Fechner, and C. S. Cho. “Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation.Immunol Rev 183 (October 2001): 205–13. https://doi.org/10.1034/j.1600-065x.2001.1830116.x.
Knechtle SJ, Hamawy MM, Hu H, Fechner JH, Cho CS. Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation. Immunol Rev. 2001 Oct;183:205–13.
Knechtle, S. J., et al. “Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation.Immunol Rev, vol. 183, Oct. 2001, pp. 205–13. Pubmed, doi:10.1034/j.1600-065x.2001.1830116.x.
Knechtle SJ, Hamawy MM, Hu H, Fechner JH, Cho CS. Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation. Immunol Rev. 2001 Oct;183:205–213.

Published In

Immunol Rev

DOI

ISSN

0105-2896

Publication Date

October 2001

Volume

183

Start / End Page

205 / 213

Location

England

Related Subject Headings

  • Transplantation Tolerance
  • Models, Animal
  • Lymphocyte Depletion
  • Kidney Transplantation
  • Immunotoxins
  • Immunology
  • Humans
  • CD40 Ligand
  • CD3 Complex
  • Animals