Simultaneous pancreas-kidney (SPK) transplantation from controlled non-heart-beating donors (NHBDs).

Journal Article (Journal Article)

From January 1993 through June 1999, 18 simultaneous pancreas-kidney transplants (SPKs) were performed from controlled non-heart-beating donors (NHBDs) and 339 SPKs were performed from heart-beating donors (HBDs). No difference in donor characteristics was noted except for warm ischemic time, which was 14.8 min (range 4-46 min) for NHBDs. Following transplantation, no difference in pancreatic function was noted; however, a higher rate of enteric conversions was seen in pancreas transplants from NHBDs (32% vs. 13%; p < 0.01). Hemodialysis for acute tubular necrosis (ATN) was higher in kidney transplants from NHBDs (22.2% vs. 4.1%; p = 0.009) as was discharge serum creatinine (1.7 mg/dl vs. 1.5 mg/dl; p < 0.05). Also, the number of patients remaining rejection free was lower for NHBDs and approached significance (33.3% vs. 50.1%; p = 0.07). However, no difference in patient survival (100% vs. 95.4%) or pancreatic (87.4% vs. 86.5%) and renal (86.3% vs. 86.3%) allograft survival was noted during the study period. Our results indicate that SPK transplantation from controlled NHBDs is a viable method for increasing the number of pancreas and kidney transplants available for transplantation.

Full Text

Duke Authors

Cited Authors

  • D'Alessandro, AM; Odorico, JS; Knechtle, SJ; Becker, YT; Hoffmann, RM; Kalayoglu, M; Sollinger, HW

Published Date

  • 2000

Published In

Volume / Issue

  • 9 / 6

Start / End Page

  • 889 - 893

PubMed ID

  • 11202574

International Standard Serial Number (ISSN)

  • 0963-6897

Digital Object Identifier (DOI)

  • 10.1177/096368970000900615


  • eng

Conference Location

  • United States