Knowledge about transplantation tolerance gained in primates.

Journal Article (Review)

Research in transplantation tolerance relies on application of successful strategies in a nonhuman-primate organ transplant model for preclinical testing. Three principal approaches are being evaluated: hematopoietic chimerism, lymphocyte depletion and costimulation blockade. Interactive work in these three areas has yielded much new information on mechanisms of tolerance and opened the door to pilot clinical trials. Clinical application of xenotransplantation is likely to depend on such strategies.

Full Text

Duke Authors

Cited Authors

  • Knechtle, SJ

Published Date

  • October 2000

Published In

Volume / Issue

  • 12 / 5

Start / End Page

  • 552 - 556

PubMed ID

  • 11007358

Electronic International Standard Serial Number (EISSN)

  • 1879-0372

International Standard Serial Number (ISSN)

  • 0952-7915

Digital Object Identifier (DOI)

  • 10.1016/s0952-7915(00)00137-0

Language

  • eng