Knowledge about transplantation tolerance gained in primates.
Journal Article (Journal Article;Review)
Research in transplantation tolerance relies on application of successful strategies in a nonhuman-primate organ transplant model for preclinical testing. Three principal approaches are being evaluated: hematopoietic chimerism, lymphocyte depletion and costimulation blockade. Interactive work in these three areas has yielded much new information on mechanisms of tolerance and opened the door to pilot clinical trials. Clinical application of xenotransplantation is likely to depend on such strategies.
- Knechtle, SJ
- October 2000
Volume / Issue
- 12 / 5
Start / End Page
- 552 - 556
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)