Surgical portosystemic shunts for treatment of portal hypertensive bleeding: outcome and effect on liver function.

Journal Article (Clinical Trial;Journal Article)

BACKGROUND: Since the advent of liver transplantation and transjugular intrahepatic portosystemic shunts (TIPS), the role of surgical portosystemic shunts in the treatment of portal hypertension has changed. However, we have continued to use portosystemic shunts in patients with noncirrhotic portal hypertension and in patients with Child's A cirrhosis. METHODS: We performed 48 surgical portosystemic shunt procedures between 1988 and 1998. The outcomes of these patients were evaluated to assess the efficacy of this treatment. Data from 39 of 48 patients were available for analysis. The average follow-up was 42 months. RESULTS: Liver function generally remained stable for the patients; only 2 patients had progressive liver failure and required transplant procedures. Gastrointestinal bleeding (3 patients), encephalopathy (3 patients), and shunt thrombosis (3 patients) were rare. Patient survival was 81% at 4 years, similar to survival with liver transplantation (P = .22). CONCLUSIONS: Surgical shunts remain the treatment of choice for prevention of recurrent variceal bleeding in patients with good liver function and portal hypertension.

Full Text

Duke Authors

Cited Authors

  • Knechtle, SJ; D'Alessandro, AM; Armbrust, MJ; Musat, A; Kalayoglu, M

Published Date

  • October 1999

Published In

Volume / Issue

  • 126 / 4

Start / End Page

  • 708 - 711

PubMed ID

  • 10520919

International Standard Serial Number (ISSN)

  • 0039-6060


  • eng

Conference Location

  • United States