Strategies for tolerance induction in nonhuman primates.

Journal Article (Journal Article;Review)

Organ transplants in nonhuman primates provide a model which closely simulates the biological conditions of human organ transplantation, due to similarities between human and primate MHC (class I and II) structure and expression. Several strategies for tolerance induction have been developed in nonhuman primate models. These include targeting the T cell receptor or costimulatory molecules and the generation of mixed chimerism. Tolerance can be reliably induced in several such models, although none with 100% success.

Full Text

Duke Authors

Cited Authors

  • Hamawy, MM; Knechtle, SJ

Published Date

  • October 1998

Published In

Volume / Issue

  • 10 / 5

Start / End Page

  • 513 - 517

PubMed ID

  • 9794834

International Standard Serial Number (ISSN)

  • 0952-7915

Digital Object Identifier (DOI)

  • 10.1016/s0952-7915(98)80216-1


  • eng

Conference Location

  • England