Strategies for tolerance induction in nonhuman primates.
Journal Article (Journal Article;Review)
Organ transplants in nonhuman primates provide a model which closely simulates the biological conditions of human organ transplantation, due to similarities between human and primate MHC (class I and II) structure and expression. Several strategies for tolerance induction have been developed in nonhuman primate models. These include targeting the T cell receptor or costimulatory molecules and the generation of mixed chimerism. Tolerance can be reliably induced in several such models, although none with 100% success.
Full Text
Duke Authors
Cited Authors
- Hamawy, MM; Knechtle, SJ
Published Date
- October 1998
Published In
Volume / Issue
- 10 / 5
Start / End Page
- 513 - 517
PubMed ID
- 9794834
Pubmed Central ID
- 9794834
International Standard Serial Number (ISSN)
- 0952-7915
Digital Object Identifier (DOI)
- 10.1016/s0952-7915(98)80216-1
Language
- eng
Conference Location
- England