Liver transplantation as definitive therapy for complications after arterial embolization for hepatic manifestations of hereditary hemorrhagic telangiectasia.

Published

Journal Article

Experience with hepatic artery embolization for the treatment of symptomatic hepatic arteriovenous malformations (AVMs) in Rendu-Osler-Weber disease is limited. We report 2 cases of hepatic AVMs that caused mesenteric angina-like symptoms that were treated with embolization. Both patients developed parenchymal and bile duct necrosis, intrahepatic bilomas, and refractory biliary sepsis, subsequently leading to liver failure. We hypothesize that the pathophysiological cause of biliary necrosis in this setting is similar to that which occurs in the setting of hepatic artery thrombosis of the liver allograft. Progressive liver failure in these patients was treated successfully by liver transplantation. Liver transplantation offers definitive therapy by removing the source of ongoing sepsis, restoring normal liver function, and eliminating the intrahepatic AV shunt.

Full Text

Duke Authors

Cited Authors

  • Odorico, JS; Hakim, MN; Becker, YT; Van der Werf, W; Musat, A; Knechtle, SJ; D'Alessandro, AM; Kalayoglu, M

Published Date

  • November 1998

Published In

Volume / Issue

  • 4 / 6

Start / End Page

  • 483 - 490

PubMed ID

  • 9791159

Pubmed Central ID

  • 9791159

International Standard Serial Number (ISSN)

  • 1074-3022

Language

  • eng

Conference Location

  • United States