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100 consecutive liver transplants in infants and children: an 8-year experience.

Publication ,  Journal Article
Eckhoff, DE; D'Alessandro, AM; Knechtle, SJ; Pirsch, JD; Ploeg, RJ; Judd, RH; Belzer, FO; Kalayoglu, M
Published in: J Pediatr Surg
August 1994

Orthotopic liver transplantation has become the treatment of choice for most children and infants with end-stage liver disease. The purpose of this retrospective study was to examine the results of 100 consecutive liver transplants performed in infants and children at a single institution. During an 8-year study period (July 1984 to December 1992), 100 pediatric liver transplants were performed in 76 patients. Thirty-four patients (44.7%) were infants (mean age, 7.0 months; mean weight, 6.1 kg), and 42 (55.3%) were children (mean age, 8.2 years; mean weight, 30.6 kg). There were 36 reduced-size liver transplants (RLT) and 64 whole-size transplants (WLT). Eight infants (23.5%) and 10 children (20.7%) required retransplantation. After transplantation, 71% of the patients had one or more rejection episodes, 66% had one or more infections, 17.1% had biliary complications, and 39.4% required one or more reoperations. There were 17 deaths. The actuarial 8-year survival rate for the patients with biliary atresia was 82.3%; for all infants in this series, it was 77.6%. No difference in patient survival was noted when RLT was compared with WLT. The overall 8-year actuarial patient survival rate for infants and children was 77.3%.

Duke Scholars

Published In

J Pediatr Surg

DOI

ISSN

0022-3468

Publication Date

August 1994

Volume

29

Issue

8

Start / End Page

1135 / 1139

Location

United States

Related Subject Headings

  • Survival Rate
  • Retrospective Studies
  • Reoperation
  • Postoperative Complications
  • Pediatrics
  • Male
  • Liver Transplantation
  • Infant
  • Humans
  • Female
 

Citation

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Eckhoff, D. E., D’Alessandro, A. M., Knechtle, S. J., Pirsch, J. D., Ploeg, R. J., Judd, R. H., … Kalayoglu, M. (1994). 100 consecutive liver transplants in infants and children: an 8-year experience. J Pediatr Surg, 29(8), 1135–1139. https://doi.org/10.1016/0022-3468(94)90295-x
Eckhoff, D. E., A. M. D’Alessandro, S. J. Knechtle, J. D. Pirsch, R. J. Ploeg, R. H. Judd, F. O. Belzer, and M. Kalayoglu. “100 consecutive liver transplants in infants and children: an 8-year experience.J Pediatr Surg 29, no. 8 (August 1994): 1135–39. https://doi.org/10.1016/0022-3468(94)90295-x.
Eckhoff DE, D’Alessandro AM, Knechtle SJ, Pirsch JD, Ploeg RJ, Judd RH, et al. 100 consecutive liver transplants in infants and children: an 8-year experience. J Pediatr Surg. 1994 Aug;29(8):1135–9.
Eckhoff, D. E., et al. “100 consecutive liver transplants in infants and children: an 8-year experience.J Pediatr Surg, vol. 29, no. 8, Aug. 1994, pp. 1135–39. Pubmed, doi:10.1016/0022-3468(94)90295-x.
Eckhoff DE, D’Alessandro AM, Knechtle SJ, Pirsch JD, Ploeg RJ, Judd RH, Belzer FO, Kalayoglu M. 100 consecutive liver transplants in infants and children: an 8-year experience. J Pediatr Surg. 1994 Aug;29(8):1135–1139.
Journal cover image

Published In

J Pediatr Surg

DOI

ISSN

0022-3468

Publication Date

August 1994

Volume

29

Issue

8

Start / End Page

1135 / 1139

Location

United States

Related Subject Headings

  • Survival Rate
  • Retrospective Studies
  • Reoperation
  • Postoperative Complications
  • Pediatrics
  • Male
  • Liver Transplantation
  • Infant
  • Humans
  • Female