Living-unrelated renal transplantation at the University of Wisconsin.
1. Use of LUrDs under a DST protocol results in a 70% actuarial graft survival at 6 years which is not statistically different from haploidentical or primary cadaver recipients transplanted over the same time period. 2. Sensitization is common, despite the use of Aza, especially in husband-to-wife donor-to-recipient relationship. 3. Rejection occurs frequently, despite the use of DST, however, it is usually reversible. The high rejection rate did not influence the quality of long-term graft survival with very few patients losing grafts to chronic rejection. 4. Expansion of the use of LUrDs could help provide additional organs for transplantation.
Pirsch, JD; D'Alessandro, AM; Sollinger, HW; Voss, BJ; Knechtle, SJ; Reed, A; Kalayoglu, M; Belzer, FO
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