Carcinosarcomas: tumors in transition?
Journal Article (Journal Article;Review)
Carcinosarcomas are rare, biphasic tumors that are comprised of carcinomatous and sarcomatous elements. While the exact mechanism by which these two phenotypes arise within a single tumor remains unclear, molecular evidence indicates that the epitheliod and spindle-cell components share a clonal origin. We propose that the biphasic nature of these neoplasms may represent an extreme case of epithelial plasticity, in which an epithelial-like cell undergoes a transition to a more mesenchymal phenotype. The present review will discuss both the histological and molecular biological evidence of the involvement of epithelial plasticity in driving the mixed phenotypes observed in carcinosarcomas.
- Somarelli, JA; Boss, M-K; Epstein, JI; Armstrong, AJ; Garcia-Blanco, MA
- June 2015
Volume / Issue
- 30 / 6
Start / End Page
- 673 - 687
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)