Rifampin use and safety in hospitalized infants.
Journal Article (Journal Article;Multicenter Study)
OBJECTIVE: This study aims to examine the use and safety of rifampin in the hospitalized infants. STUDY DESIGN: Observational study of clinical and laboratory adverse events among infants exposed to rifampin from 348 neonatal intensive care units managed by the Pediatrix Medical Group between 1997 and 2012. RESULT: Overall, 2,500 infants received 4,279 courses of rifampin; mean gestational age was 27 weeks (5th, 95th percentile; 23, 36) and mean birth weight was 1,125 g (515; 2,830). Thrombocytopenia (121/1,000 infant days) and conjugated hyperbilirubinemia (25/1,000 infant days) were the most common laboratory adverse events. The most common clinical adverse events were medical necrotizing enterocolitis (64/2,500 infants, 3%) and seizure (60/2,500 infants, 2%). CONCLUSION: The overall incidence of adverse events among infants receiving rifampin appears low; however, additional studies to further evaluate safety and dosing of rifampin in this population are needed.
- Arnold, CJ; Ericson, J; Kohman, J; Corey, KL; Oh, M; Onabanjo, J; Hornik, CP; Clark, RH; Benjamin, DK; Smith, PB; Chu, VH; Best Pharmaceuticals for Children Act–Pediatric Trials Network Administrative Core Committee,
- May 2015
Volume / Issue
- 32 / 6
Start / End Page
- 565 - 570
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)
- United States