Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization.

Journal Article (Journal Article)

Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to nitrogen-15 in pyridine and nicotinamide (vitamin B(3) amide) by conducting "signal amplification by reversible exchange" (SABRE) at microtesla fields within a magnetic shield. Following transfer of the sample from the magnetic shield chamber to a conventional NMR spectrometer, the (15)N NMR signals for these molecules are enhanced by ∼30,000- and ∼20,000-fold at 9.4 T, corresponding to ∼10% and ∼7% nuclear spin polarization, respectively. This method, dubbed "SABRE in shield enables alignment transfer to heteronuclei" or "SABRE-SHEATH", promises to be a simple, cost-effective way to hyperpolarize heteronuclei. It may be particularly useful for in vivo applications because of longer hyperpolarization lifetimes, lack of background signal, and facile chemical-shift discrimination of different species.

Full Text

Duke Authors

Cited Authors

  • Theis, T; Truong, ML; Coffey, AM; Shchepin, RV; Waddell, KW; Shi, F; Goodson, BM; Warren, WS; Chekmenev, EY

Published Date

  • February 2015

Published In

Volume / Issue

  • 137 / 4

Start / End Page

  • 1404 - 1407

PubMed ID

  • 25583142

Pubmed Central ID

  • PMC4333583

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja512242d


  • eng