Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research.

Published

Journal Article

Although transplant practices have changed over the last decades, no information is available on trends in incidence and outcome of chronic graft-versus-host disease (cGVHD) over time. This study used the central database of the Center for International Blood and Marrow Transplant Research (CIBMTR) to describe time trends for cGVHD incidence, nonrelapse mortality, and risk factors for cGVHD. The 12-year period was divided into 3 intervals, 1995 to 1999, 2000 to 2003, and 2004 to 2007, and included 26,563 patients with acute leukemia, chronic myeloid leukemia, and myelodysplastic syndrome. Multivariate analysis showed an increased incidence of cGVHD in more recent years (odds ratio = 1.19, P < .0001), and this trend was still seen when adjusting for donor type, graft type, or conditioning intensity. In patients with cGVHD, nonrelapse mortality has decreased over time, but at 5 years there were no significant differences among different time periods. Risk factors for cGVHD were in line with previous studies. This is the first comprehensive characterization of the trends in cGVHD incidence and underscores the mounting need for addressing this major late complication of transplantation in future research.

Full Text

Duke Authors

Cited Authors

  • Arai, S; Arora, M; Wang, T; Spellman, SR; He, W; Couriel, DR; Urbano-Ispizua, A; Cutler, CS; Bacigalupo, AA; Battiwalla, M; Flowers, ME; Juckett, MB; Lee, SJ; Loren, AW; Klumpp, TR; Prockup, SE; Ringdén, OTH; Savani, BN; Socié, G; Schultz, KR; Spitzer, T; Teshima, T; Bredeson, CN; Jacobsohn, DA; Hayashi, RJ; Drobyski, WR; Frangoul, HA; Akpek, G; Ho, VT; Lewis, VA; Gale, RP; Koreth, J; Chao, NJ; Aljurf, MD; Cooper, BW; Laughlin, MJ; Hsu, JW; Hematti, P; Verdonck, LF; Solh, MM; Norkin, M; Reddy, V; Martino, R; Gadalla, S; Goldberg, JD; McCarthy, PL; Pérez-Simón, JA; Khera, N; Lewis, ID; Atsuta, Y; Olsson, RF; Saber, W; Waller, EK; Blaise, D; Pidala, JA; Martin, PJ; Satwani, P; Bornhäuser, M; Inamoto, Y; Weisdorf, DJ; Horowitz, MM; Pavletic, SZ; Graft-vs-Host Disease Working Committee of the CIBMTR,

Published Date

  • February 2015

Published In

Volume / Issue

  • 21 / 2

Start / End Page

  • 266 - 274

PubMed ID

  • 25445023

Pubmed Central ID

  • 25445023

Electronic International Standard Serial Number (EISSN)

  • 1523-6536

Digital Object Identifier (DOI)

  • 10.1016/j.bbmt.2014.10.021

Language

  • eng

Conference Location

  • United States