Biological basis of bone formation, remodeling, and repair-part II: extracellular matrix.

Journal Article (Journal Article;Review)

The bony biochemical environment is a complex system that permits and promotes cellular functions that lead to matrix production and ossification. In Part I of this review, we discussed the important actions of signaling molecules, including hormones, cytokines, and growth factors. Here, we review other constituents of the extracellular matrix, including minerals, fibrinous and nonfibrinous proteins, and enzymes such as the matrix metalloproteinases. We conclude with a discussion of the role of biochemical modulation in endogenous and exogenous tissue engineering.

Full Text

Duke Authors

Cited Authors

  • Allori, AC; Sailon, AM; Warren, SM

Published Date

  • September 2008

Published In

Volume / Issue

  • 14 / 3

Start / End Page

  • 275 - 283

PubMed ID

  • 19183102

Electronic International Standard Serial Number (EISSN)

  • 1937-3376

Digital Object Identifier (DOI)

  • 10.1089/ten.teb.2008.0083


  • eng

Conference Location

  • United States