Aberrant B-cell homeostasis in chronic GVHD.

Journal Article (Journal Article;Review)

Recent studies have compelled further interest in the potential pathological role of B cells in chronic graft-versus-host disease (cGVHD). In patients with cGVHD, B cells are activated and primed for survival via B-cell activating factor and B-cell receptor-associated pathways. Understanding the signaling pathways that drive immune pathology in cGVHD will facilitate the development of new strategies to selectively target aberrantly activated B cells and restore normal B-cell homeostasis after allogeneic stem cell transplantation.

Full Text

Duke Authors

Cited Authors

  • Sarantopoulos, S; Ritz, J

Published Date

  • March 12, 2015

Published In

Volume / Issue

  • 125 / 11

Start / End Page

  • 1703 - 1707

PubMed ID

  • 25645355

Pubmed Central ID

  • PMC4357579

Electronic International Standard Serial Number (EISSN)

  • 1528-0020

Digital Object Identifier (DOI)

  • 10.1182/blood-2014-12-567834


  • eng

Conference Location

  • United States