Aberrant B-cell homeostasis in chronic GVHD.
Journal Article (Journal Article;Review)
Recent studies have compelled further interest in the potential pathological role of B cells in chronic graft-versus-host disease (cGVHD). In patients with cGVHD, B cells are activated and primed for survival via B-cell activating factor and B-cell receptor-associated pathways. Understanding the signaling pathways that drive immune pathology in cGVHD will facilitate the development of new strategies to selectively target aberrantly activated B cells and restore normal B-cell homeostasis after allogeneic stem cell transplantation.
- Sarantopoulos, S; Ritz, J
- March 12, 2015
Volume / Issue
- 125 / 11
Start / End Page
- 1703 - 1707
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)
- United States