On statistical tests for homogeneity of two bivariate zero-inflated Poisson populations.
Journal Article
The problem of testing treatment difference in the occurrence of a study endpoint in a randomized parallel-group comparative clinical trial with repeated responses under the assumption that the responses follow a bivariate zero-inflated Poisson (ZIP) distribution is considered. Likelihood ratio test for homogeneity of two bivariate ZIP populations is derived. Approximate formula for sample size calculation is also obtained, which achieves a desired power for detecting a clinically meaningful difference under an alternative hypothesis. An example concerning the comparison of treatment effect in an addictive clinical trial in terms of the number of days of illicit drug use during a month is given for illustrative purposes.
Full Text
Duke Authors
Cited Authors
- Yuen, H-K; Chow, S-C; Tse, S-K
Published Date
- 2015
Published In
Volume / Issue
- 25 / 1
Start / End Page
- 44 - 53
PubMed ID
- 24837140
Pubmed Central ID
- 24837140
Electronic International Standard Serial Number (EISSN)
- 1520-5711
Digital Object Identifier (DOI)
- 10.1080/10543406.2014.919934
Language
- eng
Conference Location
- England