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Molecular mechanisms involved in tumor repopulation after radiotherapy.

Publication ,  Journal Article
Ng, W-L; Huang, Q; Liu, X; Zimmerman, M; Li, F; Li, C-Y
Published in: Transl Cancer Res
October 1, 2013

Radiotherapy remains one of most important treatment modalities for solid tumors. Current radiotherapy is mostly based on a set of concepts called the 4"R"s, which were established when there was lack of understanding of the underlying molecular mechanisms. However, progress made in the past two decades are beginning to allow us to see some of the molecular details involved in tumor response to radiation therapy. In this review, we will attempt to summarize some of the key discoveries in molecular radiation biology that have direct relevance to radiotherapy. We will focus our discussion on areas such as radiation induced tumor vasculogenesis, stem cell mobilization, and cellular repopulation. We hope our discussion will stimulate further studies in this important area of cancer research.

Duke Scholars

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Published In

Transl Cancer Res

DOI

ISSN

2218-676X

Publication Date

October 1, 2013

Volume

2

Issue

5

Start / End Page

442 / 448

Location

China

Related Subject Headings

  • 3211 Oncology and carcinogenesis
 

Citation

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MLA
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Ng, W.-L., Huang, Q., Liu, X., Zimmerman, M., Li, F., & Li, C.-Y. (2013). Molecular mechanisms involved in tumor repopulation after radiotherapy. Transl Cancer Res, 2(5), 442–448. https://doi.org/10.3978/j.issn.2218-676X.2013.10.03
Ng, Wooi-Loon, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, and Chuan-Yuan Li. “Molecular mechanisms involved in tumor repopulation after radiotherapy.Transl Cancer Res 2, no. 5 (October 1, 2013): 442–48. https://doi.org/10.3978/j.issn.2218-676X.2013.10.03.
Ng W-L, Huang Q, Liu X, Zimmerman M, Li F, Li C-Y. Molecular mechanisms involved in tumor repopulation after radiotherapy. Transl Cancer Res. 2013 Oct 1;2(5):442–8.
Ng, Wooi-Loon, et al. “Molecular mechanisms involved in tumor repopulation after radiotherapy.Transl Cancer Res, vol. 2, no. 5, Oct. 2013, pp. 442–48. Pubmed, doi:10.3978/j.issn.2218-676X.2013.10.03.
Ng W-L, Huang Q, Liu X, Zimmerman M, Li F, Li C-Y. Molecular mechanisms involved in tumor repopulation after radiotherapy. Transl Cancer Res. 2013 Oct 1;2(5):442–448.

Published In

Transl Cancer Res

DOI

ISSN

2218-676X

Publication Date

October 1, 2013

Volume

2

Issue

5

Start / End Page

442 / 448

Location

China

Related Subject Headings

  • 3211 Oncology and carcinogenesis