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Smoking abstinence and neurocognition: implications for cessation and relapse.

Publication ,  Journal Article
McClernon, FJ; Addicott, MA; Sweitzer, MM
Published in: Curr Top Behav Neurosci
2015

In this chapter, we review the last decade of research on the effects of smoking abstinence on various forms of neurocognition, including executive function (working memory, sustained attention, response inhibition), reward processing, and cue-reactivity. In our review we identify smoking abstinence-induced deficits in executive function mediated by effects on frontal circuitry, which in turn is known to be affected by modulation of cholinergic, dopaminergic, and other neurotransmitter systems. We also review evidence that smoking abstinence blunts reactivity to non-drug reinforcers-a finding that is consistent with results in the animal literature. Finally, our review of cue-reactivity indicates that smoking abstinence does not appear to amplify cue-provoked craving, although it may increase attentional bias to smoking-related cues. Inconsistencies across findings and potential contributing factors are discussed. In addition, we review the literature on the effects of nicotine and non-nicotine factors in neurocognition. Finally, we provide a multi-factor model and an agenda for future research on the effects of smoking abstinence on neurocognition. The model includes four distinct yet interacting factors, including: Negative Reinforcement, Drug-Reward Bias, Goal and Skill Interference, and Non-Cognitive Factors. Additional research is needed to further evaluate the scope and time-course of abstinence-induced changes in neurocognition, the mechanisms that underlie these changes and the specific role of these processes in drug reinforcement, lapse, and relapse.

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Published In

Curr Top Behav Neurosci

DOI

ISSN

1866-3370

Publication Date

2015

Volume

23

Start / End Page

193 / 227

Location

Germany

Related Subject Headings

  • Substance Withdrawal Syndrome
  • Smoking
  • Reward
  • Nicotine
  • Humans
  • Executive Function
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences
 

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McClernon, F. J., Addicott, M. A., & Sweitzer, M. M. (2015). Smoking abstinence and neurocognition: implications for cessation and relapse. Curr Top Behav Neurosci, 23, 193–227. https://doi.org/10.1007/978-3-319-13665-3_8
McClernon, F Joseph, Merideth A. Addicott, and Maggie M. Sweitzer. “Smoking abstinence and neurocognition: implications for cessation and relapse.Curr Top Behav Neurosci 23 (2015): 193–227. https://doi.org/10.1007/978-3-319-13665-3_8.
McClernon FJ, Addicott MA, Sweitzer MM. Smoking abstinence and neurocognition: implications for cessation and relapse. Curr Top Behav Neurosci. 2015;23:193–227.
McClernon, F. Joseph, et al. “Smoking abstinence and neurocognition: implications for cessation and relapse.Curr Top Behav Neurosci, vol. 23, 2015, pp. 193–227. Pubmed, doi:10.1007/978-3-319-13665-3_8.
McClernon FJ, Addicott MA, Sweitzer MM. Smoking abstinence and neurocognition: implications for cessation and relapse. Curr Top Behav Neurosci. 2015;23:193–227.

Published In

Curr Top Behav Neurosci

DOI

ISSN

1866-3370

Publication Date

2015

Volume

23

Start / End Page

193 / 227

Location

Germany

Related Subject Headings

  • Substance Withdrawal Syndrome
  • Smoking
  • Reward
  • Nicotine
  • Humans
  • Executive Function
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences