Educational attainment and hippocampal atrophy in the Alzheimer's disease neuroimaging initiative cohort


Journal Article

© 2014 Elsevier Masson SAS. Introduction: Subjects with higher cognitive reserve (CR) may be at a lower risk for Alzheimer's disease (AD), but the neural mechanisms underlying this are not known. Hippocampal volume loss is an early event in AD that triggers cognitive decline. Materials and methods: Regression analyses of the effects of education on MRI-measured baseline HV in 675 subjects (201 normal, 329 with mild cognitive impairment (MCI), and 146 subjects with mild AD), adjusting for age, gender, APOE e{open}4 status and intracranial volume (ICV). Subjects were derived from the Alzheimer's Disease Neuroimaging Initiative (ADNI), a large US national biomarker study. Results: The association between higher education and larger HV was significant in AD (P= 0.014) but not in cognitively normal or MCI subjects. In AD, HV was about 8% larger in a person with 20 years of education relative to someone with 6 years of education. There was also a trend for the interaction between education and APOE e{open}4 to be significant in AD (P= 0.056). Conclusion: A potential protective association between higher education and lower hippocampal atrophy in patients with AD appears consistent with prior epidemiologic data linking higher education levels with lower rates of incident dementia. Longitudinal studies are warranted to confirm these findings.

Full Text

Duke Authors

Cited Authors

  • Shpanskaya, KS; Choudhury, KR; Hostage, C; Murphy, KR; Petrella, JR; Doraiswamy, PM

Published Date

  • December 1, 2014

Published In

Volume / Issue

  • 41 / 5

Start / End Page

  • 350 - 357

Electronic International Standard Serial Number (EISSN)

  • 1773-0406

International Standard Serial Number (ISSN)

  • 0150-9861

Digital Object Identifier (DOI)

  • 10.1016/j.neurad.2013.11.004

Citation Source

  • Scopus