COPD: balancing oxidants and antioxidants.

Published

Journal Article (Review)

Chronic obstructive pulmonary disease (COPD) is one of the most common chronic illnesses in the world. The disease encompasses emphysema, chronic bronchitis, and small airway obstruction and can be caused by environmental exposures, primarily cigarette smoking. Since only a small subset of smokers develop COPD, it is believed that host factors interact with the environment to increase the propensity to develop disease. The major pathogenic factors causing disease include infection and inflammation, protease and antiprotease imbalance, and oxidative stress overwhelming antioxidant defenses. In this review, we will discuss the major environmental and host sources for oxidative stress; discuss how oxidative stress regulates chronic bronchitis; review the latest information on genetic predisposition to COPD, specifically focusing on oxidant/antioxidant imbalance; and review future antioxidant therapeutic options for COPD. The complexity of COPD will necessitate a multi-target therapeutic approach. It is likely that antioxidant supplementation and dietary antioxidants will have a place in these future combination therapies.

Full Text

Duke Authors

Cited Authors

  • Fischer, BM; Voynow, JA; Ghio, AJ

Published Date

  • January 2015

Published In

Volume / Issue

  • 10 /

Start / End Page

  • 261 - 276

PubMed ID

  • 25673984

Pubmed Central ID

  • 25673984

Electronic International Standard Serial Number (EISSN)

  • 1178-2005

International Standard Serial Number (ISSN)

  • 1176-9106

Digital Object Identifier (DOI)

  • 10.2147/COPD.S42414

Language

  • eng