Rational opioid dosing in the elderly: dose and dosing interval when initiating opioid therapy.

Journal Article (Journal Article)

Opioids are the mainstay of treatment for moderate to severe pain. However, opioid therapy in the elderly is often associated with significant morbidity because of excessive ventilatory depression. The large amount of interindividual variability in opioid dose-response relationships makes it difficult to individualize the dose and dosing interval to provide safe and effective analgesia. By examining how aging affects the pharmacokinetics (PK) and pharmacodynamics (PD) of opioids, it is possible to provide a rational basis for age adjustment in opioid dosing.

Full Text

Duke Authors

Cited Authors

  • Gupta, DK; Avram, MJ

Published Date

  • February 2012

Published In

Volume / Issue

  • 91 / 2

Start / End Page

  • 339 - 343

PubMed ID

  • 22205194

Electronic International Standard Serial Number (EISSN)

  • 1532-6535

Digital Object Identifier (DOI)

  • 10.1038/clpt.2011.307


  • eng

Conference Location

  • United States