Inhaled anesthesia: the original closed-loop drug administration paradigm.

Journal Article (Journal Article;Review)

We administer anesthetics to obtain therapeutic effects and minimize untoward side effects. Anesthetists can precisely control inhaled anesthetic concentrations by controlling end-tidal volatile anesthetic concentrations. This degree of control eliminates the need for closed-loop inhaled anesthetic systems. The low solubility of modern inhaled anesthetics adds to the stability and control of the anesthetic state; the effective inhaled concentration varies little during maintenance of anesthesia unless altered by the anesthetist. A less precise closed-loop system applies a processed electroencephalogram (EEG) to assess depth of anesthesia and enable accurate delivery of volatile and intravenous anesthetics to maintain a stable state of anesthesia.

Full Text

Duke Authors

Cited Authors

  • Gupta, DK; Eger, EI

Published Date

  • July 2008

Published In

Volume / Issue

  • 84 / 1

Start / End Page

  • 15 - 18

PubMed ID

  • 18563068

Electronic International Standard Serial Number (EISSN)

  • 1532-6535

Digital Object Identifier (DOI)

  • 10.1038/clpt.2008.85


  • eng

Conference Location

  • United States