Skip to main content

Attribution of 12 high-risk human papillomavirus genotypes to infection and cervical disease.

Publication ,  Journal Article
Joura, EA; Ault, KA; Bosch, FX; Brown, D; Cuzick, J; Ferris, D; Garland, SM; Giuliano, AR; Hernandez-Avila, M; Huh, W; Iversen, O-E; Kjaer, SK ...
Published in: Cancer Epidemiol Biomarkers Prev
October 2014

BACKGROUND: We estimated the prevalence and incidence of 14 human papillomavirus (HPV) types (6/11/16/18/31/33/35/39/45/51/52/56/58/59) in cervicovaginal swabs, and the attribution of these HPV types in cervical intraepithelial neoplasia (CIN), and adenocarcinoma in situ (AIS), using predefined algorithms that adjusted for multiple-type infected lesions. METHODS: A total of 10,656 women ages 15 to 26 years and 1,858 women ages 24 to 45 years were enrolled in the placebo arms of one of three clinical trials of a quadrivalent HPV vaccine. We estimated the cumulative incidence of persistent infection and the proportion of CIN/AIS attributable to individual carcinogenic HPV genotypes, as well as the proportion of CIN/AIS lesions potentially preventable by a prophylactic 9-valent HPV6/11/16/18/31/33/45/52/58 vaccine. RESULTS: The cumulative incidence of persistent infection with ≥1 of the seven high-risk types included in the 9-valent vaccine was 29%, 12%, and 6% for women ages 15 to 26, 24 to 34, and 35 to 45 years, respectively. A total of 2,507 lesions were diagnosed as CIN or AIS by an expert pathology panel. After adjusting for multiple-type infected lesions, among women ages 15 to 45 years, these seven high-risk types were attributed to 43% to 55% of CIN1, 70% to 78% of CIN2, 85% to 91% of CIN3, and 95% to 100% of AIS lesions, respectively. The other tested types (HPV35/39/51/56/59) were attributed to 23% to 30% of CIN1, 7% to 14% of CIN2, 3% to 4% of CIN3, and 0% of AIS lesions, respectively. CONCLUSIONS: Approximately 85% or more of CIN3/AIS, >70% CIN2, and approximately 50% of CIN1 lesions worldwide are attributed to HPV6/11/16/18/31/33/45/52/58. IMPACT: If 9-valent HPV vaccination programs are effectively implemented, the majority of CIN2 and CIN3 lesions worldwide could be prevented, in addition to approximately one-half of CIN1.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

October 2014

Volume

23

Issue

10

Start / End Page

1997 / 2008

Location

United States

Related Subject Headings

  • Young Adult
  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Risk Factors
  • Prevalence
  • Papillomavirus Vaccines
  • Papillomavirus Infections
  • Papillomaviridae
  • Middle Aged
  • Incidence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Joura, E. A., Ault, K. A., Bosch, F. X., Brown, D., Cuzick, J., Ferris, D., … Velicer, C. (2014). Attribution of 12 high-risk human papillomavirus genotypes to infection and cervical disease. Cancer Epidemiol Biomarkers Prev, 23(10), 1997–2008. https://doi.org/10.1158/1055-9965.EPI-14-0410
Joura, Elmar A., Kevin A. Ault, F Xavier Bosch, Darron Brown, Jack Cuzick, Daron Ferris, Suzanne M. Garland, et al. “Attribution of 12 high-risk human papillomavirus genotypes to infection and cervical disease.Cancer Epidemiol Biomarkers Prev 23, no. 10 (October 2014): 1997–2008. https://doi.org/10.1158/1055-9965.EPI-14-0410.
Joura EA, Ault KA, Bosch FX, Brown D, Cuzick J, Ferris D, et al. Attribution of 12 high-risk human papillomavirus genotypes to infection and cervical disease. Cancer Epidemiol Biomarkers Prev. 2014 Oct;23(10):1997–2008.
Joura, Elmar A., et al. “Attribution of 12 high-risk human papillomavirus genotypes to infection and cervical disease.Cancer Epidemiol Biomarkers Prev, vol. 23, no. 10, Oct. 2014, pp. 1997–2008. Pubmed, doi:10.1158/1055-9965.EPI-14-0410.
Joura EA, Ault KA, Bosch FX, Brown D, Cuzick J, Ferris D, Garland SM, Giuliano AR, Hernandez-Avila M, Huh W, Iversen O-E, Kjaer SK, Luna J, Miller D, Monsonego J, Munoz N, Myers E, Paavonen J, Pitisuttithum P, Steben M, Wheeler CM, Perez G, Saah A, Luxembourg A, Sings HL, Velicer C. Attribution of 12 high-risk human papillomavirus genotypes to infection and cervical disease. Cancer Epidemiol Biomarkers Prev. 2014 Oct;23(10):1997–2008.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

October 2014

Volume

23

Issue

10

Start / End Page

1997 / 2008

Location

United States

Related Subject Headings

  • Young Adult
  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Risk Factors
  • Prevalence
  • Papillomavirus Vaccines
  • Papillomavirus Infections
  • Papillomaviridae
  • Middle Aged
  • Incidence