Rhabdomyosarcomatous Transformation of a Gastrointestinal Stromal Tumor following Treatment with Imatinib.

Journal Article (Journal Article)

Rhabdomyosarcomatous dedifferentiation of GIST following tyrosine kinase inhibitor (TKI) therapy is rare, with only a handful of cases previously reported in the literature. Herein we present a case of metastatic GIST initially treated with imatinib that developed radiographic evidence of progression after 8 months of standard dose therapy with continued progression despite attempts at using dose-escalated imatinib 400 mg bid. Due to the patient's worsening clinical symptoms and radiographic concerns for colonic thickening, abscess, and extraluminal air, the patient underwent a palliative resection of a large heterogeneous mass arising from the posterior stomach and several metastatic foci. Pathology revealed a dedifferentiated GIST with rhabdomyosarcomatous features. This report will highlight the unique features of this case and review the existing literature.

Full Text

Duke Authors

Cited Authors

  • Jiang, X; Anderson, HB; Guy, CD; Mosca, PJ; Riedel, RF; Cardona, DM

Published Date

  • 2015

Published In

Volume / Issue

  • 2015 /

Start / End Page

  • 317493 -

PubMed ID

  • 25694839

Pubmed Central ID

  • PMC4324915

International Standard Serial Number (ISSN)

  • 2090-6706

Digital Object Identifier (DOI)

  • 10.1155/2015/317493


  • eng

Conference Location

  • United States