Astrocytes Control Synapse Formation, Function, and Elimination.

Journal Article (Journal Article;Review)

Astrocytes, through their close associations with synapses, can monitor and alter synaptic function, thus actively controlling synaptic transmission in the adult brain. Besides their important role at adult synapses, in the last three decades a number of critical findings have highlighted the importance of astrocytes in the establishment of synaptic connectivity in the developing brain. In this article, we will review the key findings on astrocytic control of synapse formation, function, and elimination. First, we will summarize our current structural and functional understanding of astrocytes at the synapse. Then, we will discuss the cellular and molecular mechanisms through which developing and mature astrocytes instruct the formation, maturation, and refinement of synapses. Our aim is to provide an overview of astrocytes as important players in the establishment of a functional nervous system.

Full Text

Duke Authors

Cited Authors

  • Chung, W-S; Allen, NJ; Eroglu, C

Published Date

  • February 6, 2015

Published In

Volume / Issue

  • 7 / 9

Start / End Page

  • a020370 -

PubMed ID

  • 25663667

Pubmed Central ID

  • PMC4527946

Electronic International Standard Serial Number (EISSN)

  • 1943-0264

Digital Object Identifier (DOI)

  • 10.1101/cshperspect.a020370


  • eng

Conference Location

  • United States