Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss.


Journal Article

Taking a genome-wide association study approach, we identified inherited genetic variations in ACYP2 associated with cisplatin-related ototoxicity (rs1872328: P = 3.9 × 10(-8), hazard ratio = 4.5) in 238 children with newly diagnosed brain tumors, with independent replication in 68 similarly treated children. The ACYP2 risk variant strongly predisposed these patients to precipitous hearing loss and was related to ototoxicity severity. These results point to new biology underlying the ototoxic effects of platinum agents.

Full Text

Cited Authors

  • Xu, H; Robinson, GW; Huang, J; Lim, JY-S; Zhang, H; Bass, JK; Broniscer, A; Chintagumpala, M; Bartels, U; Gururangan, S; Hassall, T; Fisher, M; Cohn, R; Yamashita, T; Teitz, T; Zuo, J; Onar-Thomas, A; Gajjar, A; Stewart, CF; Yang, JJ

Published Date

  • March 2015

Published In

Volume / Issue

  • 47 / 3

Start / End Page

  • 263 - 266

PubMed ID

  • 25665007

Pubmed Central ID

  • 25665007

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng.3217


  • eng