Perinatal cytomegalovirus and varicella zoster virus infections: epidemiology, prevention, and treatment.

Journal Article (Journal Article;Review)

Mother-to-child transmission of cytomegalovirus (CMV) and varicella zoster virus (VZV) can lead to severe birth defects and neurologic impairment of infants. Congenital CMV complicates up to 1% of all pregnancies globally. Although antiviral treatment of infants congenitally infected with CMV can ameliorate the CMV-associated hearing loss and developmental delay, interventions to prevent congenital CMV infection and the associated neurologic impairments are still being evaluated. Congenital VZV infection is rare. Active and passive immunization strategies to prevent perinatal CMV infection with similar efficacy to those established to prevent perinatal VZV infections are critically needed in pediatric health.

Full Text

Duke Authors

Cited Authors

  • Bialas, KM; Swamy, GK; Permar, SR

Published Date

  • March 2015

Published In

Volume / Issue

  • 42 / 1

Start / End Page

  • 61 - viii

PubMed ID

  • 25677997

Pubmed Central ID

  • PMC4328139

Electronic International Standard Serial Number (EISSN)

  • 1557-9840

Digital Object Identifier (DOI)

  • 10.1016/j.clp.2014.10.006


  • eng

Conference Location

  • United States