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Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma.

Publication ,  Journal Article
Matty, MA; Roca, FJ; Cronan, MR; Tobin, DM
Published in: Immunol Rev
March 2015

Recent work in a variety of animal models, including mice, zebrafish, and macaques, as well as in humans, has led to a reassessment of several tenets of mycobacterial infection. In this review, we describe new findings about the composition and dynamics of the tuberculous granuloma, the central host structure in mycobacterial infection, as well as inflammatory mediators that drive a successful anti-microbial response on one hand and pathological inflammation on the other. We highlight granuloma heterogeneity that emerges in the context of infection, the functional consequences of angiogenesis in tuberculous granulomas, and data that balanced inflammation in humans, with a central role for tumor necrosis factor, appears to play a key role in optimal defense against mycobacterial infection. These findings have suggested new and specific host-directed therapies that await further clinical exploration.

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Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

March 2015

Volume

264

Issue

1

Start / End Page

276 / 287

Location

England

Related Subject Headings

  • Tuberculosis
  • Neovascularization, Pathologic
  • Mycobacterium tuberculosis
  • Inflammation Mediators
  • Immunology
  • Hypoxia
  • Humans
  • Granuloma
  • Eicosanoids
  • Cytokines
 

Citation

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Matty, M. A., Roca, F. J., Cronan, M. R., & Tobin, D. M. (2015). Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma. Immunol Rev, 264(1), 276–287. https://doi.org/10.1111/imr.12273
Matty, Molly A., Francisco J. Roca, Mark R. Cronan, and David M. Tobin. “Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma.Immunol Rev 264, no. 1 (March 2015): 276–87. https://doi.org/10.1111/imr.12273.
Matty, Molly A., et al. “Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma.Immunol Rev, vol. 264, no. 1, Mar. 2015, pp. 276–87. Pubmed, doi:10.1111/imr.12273.
Journal cover image

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

March 2015

Volume

264

Issue

1

Start / End Page

276 / 287

Location

England

Related Subject Headings

  • Tuberculosis
  • Neovascularization, Pathologic
  • Mycobacterium tuberculosis
  • Inflammation Mediators
  • Immunology
  • Hypoxia
  • Humans
  • Granuloma
  • Eicosanoids
  • Cytokines