The reproducibility and absolute values of echocardiographic measurements of left ventricular size and function in children are algorithm dependent.

Journal Article (Journal Article;Multicenter Study)

BACKGROUND: Several quantification algorithms for measuring left ventricular (LV) size and function are used in clinical and research settings. The aims of this study were to investigate the effects of measurement algorithm and beat averaging on the reproducibility of measurements of the left ventricle and to assess the magnitude of agreement among the algorithms in children with dilated cardiomyopathy. METHODS: Echocardiograms were obtained in 169 children from eight clinical centers. Inter- and intrareader reproducibility was assessed on measurements of LV volumes using the biplane Simpson, modified Simpson, and 5/6 × area × length (5/6AL) algorithms. Percentage error was calculated as inter- or intrareader difference/mean × 100. Single-beat measurements and the three-beat average (3BA) were compared. Intraclass correlation coefficients were calculated to assess agreement. RESULTS: Single-beat interreader reproducibility was lowest (percentage error was highest) using biplane Simpson; 5/6AL and modified Simpson were similar but significantly better than biplane Simpson (P < .05). Single-beat intrareader reproducibility was highest using 5/6AL (P < .05). The 3BA improved reproducibility for almost all measures (P < .05). Reproducibility in both single-beat and 3BA values fell with greater LV dilation and systolic dysfunction (P < .05). Intraclass correlation coefficients were >0.95 across measures, although absolute volume and mass values were systematically lower for biplane Simpson compared with modified Simpson and 5/6AL. CONCLUSIONS: The reproducibility of LV size and functional measurements in children with dilated cardiomyopathy is highest using the 5/6AL algorithm and can be further improved by using the 3BA. However, values derived from different algorithms are not interchangeable.

Full Text

Duke Authors

Cited Authors

  • Margossian, R; Chen, S; Sleeper, LA; Tani, LY; Shirali, G; Golding, F; Selamet Tierney, ES; Altmann, K; Campbell, MJ; Szwast, A; Sharkey, A; Radojewski, E; Colan, SD; Pediatric Heart Network Investigators,

Published Date

  • May 2015

Published In

Volume / Issue

  • 28 / 5

Start / End Page

  • 549 - 558.e1

PubMed ID

  • 25728351

Pubmed Central ID

  • PMC4426088

Electronic International Standard Serial Number (EISSN)

  • 1097-6795

Digital Object Identifier (DOI)

  • 10.1016/j.echo.2015.01.014


  • eng

Conference Location

  • United States