The periprocedural management of novel oral anticoagulants in patients with nonvalvular atrial fibrillation: rationale and a summary of the available evidence from phase 3 clinical trials.

Journal Article (Journal Article;Review)

The novel oral anticoagulants (NOACs) have rapidly emerged as an alternative therapy to warfarin. Several recent phase 3 randomized control trials have demonstrated the efficacy and safety of the NOACs in the treatment for patients with nonvalvular atrial fibrillation. As the NOACs are incorporated in clinical practice, questions have begun to arise concerning their optimal use in commonly encountered situations. In this review, we provide a summary of the available evidence from the phase 3 randomized control trials specifically with regard to 1 such scenario, the periprocedural management of NOACs, with a goal of providing guidance for practicing clinicians.

Full Text

Duke Authors

Cited Authors

  • Krishnamoorthy, A; Sherwood, MW; Lopes, RD; Becker, RC

Published Date

  • March 2015

Published In

Volume / Issue

  • 169 / 3

Start / End Page

  • 315 - 322

PubMed ID

  • 25728720

Electronic International Standard Serial Number (EISSN)

  • 1097-6744

Digital Object Identifier (DOI)

  • 10.1016/j.ahj.2014.12.008


  • eng

Conference Location

  • United States