A confidence ellipse for the Net Reclassification Improvement.


Journal Article

The Net Reclassification Improvement (NRI) has become a popular metric for evaluating improvement in disease prediction models through the past years. The concept is relatively straightforward but usage and interpretation has been different across studies. While no thresholds exist for evaluating the degree of improvement, many studies have relied solely on the significance of the NRI estimate. However, recent studies recommend that statistical testing with the NRI should be avoided. We propose using confidence ellipses around the estimated values of event and non-event NRIs which might provide the best measure of variability around the point estimates. Our developments are illustrated using practical examples from EPIC-Potsdam study.

Full Text

Duke Authors

Cited Authors

  • Mühlenbruch, K; Kuxhaus, O; Pencina, MJ; Boeing, H; Liero, H; Schulze, MB

Published Date

  • April 2015

Published In

Volume / Issue

  • 30 / 4

Start / End Page

  • 299 - 304

PubMed ID

  • 25724473

Pubmed Central ID

  • 25724473

Electronic International Standard Serial Number (EISSN)

  • 1573-7284

Digital Object Identifier (DOI)

  • 10.1007/s10654-015-0001-1


  • eng

Conference Location

  • Netherlands