Genetic variants are not associated with outcome in patients with coronary artery disease and left ventricular dysfunction: results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials.

Published

Journal Article

We evaluated the ability of 23 genetic variants to provide prognostic information in patients enrolled in the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials.Patients assigned to STICH Hypothesis 1 were randomized to medical therapy with or without coronary artery bypass grafting (CABG). Those assigned to STICH Hypothesis 2 were randomized to CABG or CABG with left ventricular reconstruction.In patients assigned to STICH Hypothesis 2 (n = 714), no genetic variant met the prespecified Bonferroni-adjusted threshold for statistical significance (p < 0.002); however, several variants met nominal prognostic significance: variants in the β2-adrenergic receptor gene (β2-AR Gln27Glu) and in the A1-adenosine receptor gene (A1-717 T/G) were associated with an increased risk of a subject dying or being hospitalized for a cardiac problem (p = 0.027 and 0.031, respectively). These relationships remained nominally significant even after multivariable adjustment for prognostic clinical variables. However, none of the 23 genetic variants influenced all-cause mortality or the combination of death or cardiovascular hospitalization in the STICH Hypothesis 1 population (n = 532) by either univariate or multivariable analysis.We were unable to identify the predictive genotypes in optimally treated patients in these two ischemic heart failure populations.

Full Text

Duke Authors

Cited Authors

  • Feldman, AM; She, L; McNamara, DM; Mann, DL; Bristow, MR; Maisel, AS; Wagner, DR; Andersson, B; Chiariello, L; Hayward, CS; Hendry, P; Parker, JD; Racine, N; Selzman, CH; Senni, M; Stepinska, J; Zembala, M; Rouleau, J; Velazquez, EJ; Lee, KL

Published Date

  • January 13, 2015

Published In

Volume / Issue

  • 130 / 2

Start / End Page

  • 69 - 81

PubMed ID

  • 25592552

Pubmed Central ID

  • 25592552

Electronic International Standard Serial Number (EISSN)

  • 1421-9751

International Standard Serial Number (ISSN)

  • 0008-6312

Digital Object Identifier (DOI)

  • 10.1159/000368221

Language

  • eng