Sino-implant (II)® continuation and effect of concomitant tenofovir disoproxil fumarate-emtricitabine use on plasma levonorgestrel concentrations among women in Bondo, Kenya.


Journal Article

The objective was to assess associations between tenofovir disoproxil fumarate-emtricitabine (TDF-FTC) exposure and levonorgestrel (LNG) concentrations among Kenyan HIV prevention trial participants using Sino-implant (II) LNG implants for contraception.Women were offered implants among other contraceptive methods, were randomized to daily TDF-FTC or placebo, and followed monthly up to 56weeks. Associations between TDF-FTC exposure and mean LNG values were analyzed with linear mixed models.Of 739 women, 29 (3.9%) received implants with no incident pregnancies and one discontinuation. Mean LNG concentrations over 56weeks among 28 women contributing data ranged between 214.0 and 659.8pg/mL with no significant difference between TDF-FTC and placebo arms or between variable levels of TDF-FTC adherence.Concomitant TDF-FTC use was not associated with a significant change in plasma LNG concentrations among women using Sino-implant (II) in the first year of use.

Full Text

Cited Authors

  • Todd, CS; Deese, J; Wang, M; Hubacher, D; Steiner, MJ; Otunga, S; Van Damme, L; FEM-PrEP Study Group,

Published Date

  • March 2015

Published In

Volume / Issue

  • 91 / 3

Start / End Page

  • 248 - 252

PubMed ID

  • 25459097

Pubmed Central ID

  • 25459097

Electronic International Standard Serial Number (EISSN)

  • 1879-0518

International Standard Serial Number (ISSN)

  • 0010-7824

Digital Object Identifier (DOI)

  • 10.1016/j.contraception.2014.10.008


  • eng