Patient-reported outcomes as end points and outcome indicators in solid tumours.


Journal Article (Review)

Patient-reported outcome (PRO) measures, such as quality of life, have been associated with relevant clinical end points and are prognostic for survival outcomes in a variety of solid cancers in adults. In the past few years, PROs have garnered a greater influence as established and clinically relevant measures that could alter the current paradigm of practice-changing therapeutic advances, as it has been recognized that classic clinical end points do not accurately portray a full appreciation of the benefits, risks and costs of therapy. In this Review, we comprehensively assess the correlation of PROs with treatment response and survival, and explore tumour-related and patient-centric composite end points in patients with cancer participating in clinical trials. Comparisons or composite end points that consider tumour-related and PRO components might help health-care providers, patients with cancer and decision makers to better understand the total clinical benefit of therapeutic interventions.

Full Text

Duke Authors

Cited Authors

  • Secord, AA; Coleman, RL; Havrilesky, LJ; Abernethy, AP; Samsa, GP; Cella, D

Published Date

  • June 2015

Published In

Volume / Issue

  • 12 / 6

Start / End Page

  • 358 - 370

PubMed ID

  • 25754949

Pubmed Central ID

  • 25754949

Electronic International Standard Serial Number (EISSN)

  • 1759-4782

Digital Object Identifier (DOI)

  • 10.1038/nrclinonc.2015.29


  • eng

Conference Location

  • England