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Patient-reported outcomes as end points and outcome indicators in solid tumours.

Publication ,  Journal Article
Secord, AA; Coleman, RL; Havrilesky, LJ; Abernethy, AP; Samsa, GP; Cella, D
Published in: Nat Rev Clin Oncol
June 2015

Patient-reported outcome (PRO) measures, such as quality of life, have been associated with relevant clinical end points and are prognostic for survival outcomes in a variety of solid cancers in adults. In the past few years, PROs have garnered a greater influence as established and clinically relevant measures that could alter the current paradigm of practice-changing therapeutic advances, as it has been recognized that classic clinical end points do not accurately portray a full appreciation of the benefits, risks and costs of therapy. In this Review, we comprehensively assess the correlation of PROs with treatment response and survival, and explore tumour-related and patient-centric composite end points in patients with cancer participating in clinical trials. Comparisons or composite end points that consider tumour-related and PRO components might help health-care providers, patients with cancer and decision makers to better understand the total clinical benefit of therapeutic interventions.

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Published In

Nat Rev Clin Oncol

DOI

EISSN

1759-4782

Publication Date

June 2015

Volume

12

Issue

6

Start / End Page

358 / 370

Location

England

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Self Report
  • Quality of Life
  • Patient-Centered Care
  • Patient Outcome Assessment
  • Neoplasms
  • Humans
  • Forecasting
  • Clinical Trials as Topic
 

Citation

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Secord, A. A., Coleman, R. L., Havrilesky, L. J., Abernethy, A. P., Samsa, G. P., & Cella, D. (2015). Patient-reported outcomes as end points and outcome indicators in solid tumours. Nat Rev Clin Oncol, 12(6), 358–370. https://doi.org/10.1038/nrclinonc.2015.29
Secord, Angeles A., Robert L. Coleman, Laura J. Havrilesky, Amy P. Abernethy, Gregory P. Samsa, and David Cella. “Patient-reported outcomes as end points and outcome indicators in solid tumours.Nat Rev Clin Oncol 12, no. 6 (June 2015): 358–70. https://doi.org/10.1038/nrclinonc.2015.29.
Secord AA, Coleman RL, Havrilesky LJ, Abernethy AP, Samsa GP, Cella D. Patient-reported outcomes as end points and outcome indicators in solid tumours. Nat Rev Clin Oncol. 2015 Jun;12(6):358–70.
Secord, Angeles A., et al. “Patient-reported outcomes as end points and outcome indicators in solid tumours.Nat Rev Clin Oncol, vol. 12, no. 6, June 2015, pp. 358–70. Pubmed, doi:10.1038/nrclinonc.2015.29.
Secord AA, Coleman RL, Havrilesky LJ, Abernethy AP, Samsa GP, Cella D. Patient-reported outcomes as end points and outcome indicators in solid tumours. Nat Rev Clin Oncol. 2015 Jun;12(6):358–370.

Published In

Nat Rev Clin Oncol

DOI

EISSN

1759-4782

Publication Date

June 2015

Volume

12

Issue

6

Start / End Page

358 / 370

Location

England

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Self Report
  • Quality of Life
  • Patient-Centered Care
  • Patient Outcome Assessment
  • Neoplasms
  • Humans
  • Forecasting
  • Clinical Trials as Topic