Extent and reasons for nonadherence to antihypertensive, cholesterol, and diabetes medications: the association with depressive symptom burden in a sample of American veterans.

Published online

Journal Article

OBJECTIVE: Persons with depressive symptoms generally have higher rates of medication nonadherence than persons without depressive symptoms. However, little is known about whether this association differs by comorbid medical condition or whether reasons for nonadherence differ by depressive symptoms or comorbid medical condition. METHODS: Self-reported extent of nonadherence, reasons for nonadherence, and depressive symptoms among 1,026 veterans prescribed medications for hypertension, dyslipidemia, and/or type 2 diabetes were assessed. RESULTS: In multivariable logistic regression adjusted for clinical and demographic factors, the odds of nonadherence were higher among participants with high depressive symptom burden for dyslipidemia (n=848; odds ratio [OR]: 1.42, P=0.03) but not hypertension (n=916; OR: 1.24, P=0.15), or type 2 diabetes (n=447; OR: 1.15, P=0.51). Among participants reporting nonadherence to antihypertensive and antilipemic medications, those with greater depressive symptom burden had greater odds of endorsing medication nonadherence reasons related to negative expectations and excessive economic burden. Neither extent of nonadherence nor reasons for nonadherence differed by depressive symptom burden among patients with diabetes. CONCLUSION: These findings suggest that clinicians may consider tailoring interventions to improve adherence to antihypertensive and antilipemic medications to specific medication concerns of participants with depressive symptoms.

Full Text

Duke Authors

Cited Authors

  • Weidenbacher, HJ; Beadles, CA; Maciejewski, ML; Reeve, BB; Voils, CI

Published Date

  • 2015

Published In

Volume / Issue

  • 9 /

Start / End Page

  • 327 - 336

PubMed ID

  • 25759567

Pubmed Central ID

  • 25759567

International Standard Serial Number (ISSN)

  • 1177-889X

Digital Object Identifier (DOI)

  • 10.2147/PPA.S74531

Language

  • eng

Conference Location

  • New Zealand