Intra-aneurysmal thrombus modification after flow-diversion.


Journal Article

Flow diversion has been successfully used to treat large and giant intracranial aneurysms that present with mass effect. We conducted a retrospective review, evaluating the modification of thrombi in this aneurysm type after treatment with the Pipeline Embolization Device (ev3 Endovascular, Plymouth, MN, USA) and the effects of these modifications on symptoms. Eight patients, seven of whom were female, harbored eight partially thrombosed large or giant aneurysms. Five of the eight aneurysms presented with symptomatic mass effect. At 1 year follow-up, complete occlusion occurred in 75% (6/8) of patients. On average, the longest thrombus diameter measured 22.31 mm before treatment and 14.05 mm 1 year afterwards. Seven of the eight thrombi regressed, as did their aneurysms. All six patients with shrunken thrombi had tremendous symptom improvement and became asymptomatic in the following year. The current findings seem to reflect the size variation of the intra-aneurysmal thrombus rather than the size of the aneurysm itself.

Full Text

Duke Authors

Cited Authors

  • Zanaty, M; Jabbour, PM; Bou Sader, R; Chalouhi, N; Tjoumakaris, S; Rosenwasser, RH; Fernando Gonzalez, L

Published Date

  • January 2015

Published In

Volume / Issue

  • 22 / 1

Start / End Page

  • 105 - 110

PubMed ID

  • 25192591

Pubmed Central ID

  • 25192591

Electronic International Standard Serial Number (EISSN)

  • 1532-2653

Digital Object Identifier (DOI)

  • 10.1016/j.jocn.2014.05.033


  • eng

Conference Location

  • Scotland